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clomipramine decreases outcomes of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Prevents conversion of codeine to its Energetic metabolite morphine.

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buprenorphine subdermal implant and codeine equally boost sedation. Avoid or Use Alternate Drug. Restrict use to clients for whom alternative therapy alternatives are insufficient

clobazam decreases Makatussin Syrop consequences of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Helps prevent conversion of codeine to its active metabolite morphine.

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Sufferers with an “ultrafast CYP2D6 metabolizer” phenotype Use a superior CYP2D6 action, so harmful serum levels of morphine can occur even at lower doses.